During the LSD-bound crystal composition, the side chain with the lid residue L209EL2 types comprehensive hydrophobic contacts with both of those LSD and encompassing residues in TMs III, IV, and V (Determine 4C). When the lid moved aside to reveal the binding pocket in simulation, many of such contacts broke. https://my-social-box.com/story4989791/the-lsd-crystal-diaries