Pentobarbital will decrease the level or effect of hydrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of zonisamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Acting as both a sedative and a hypnotic, pentobarbital can be prescribed for the short-term t... https://bookmarkprobe.com/story20569121/i-pentobarbital-icp-diaries