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Respiratory depression is easily the most feared adverse effect of opioids — plus the main cause of opioid-connected death. Tramadol’s ceiling effect on μ-opioid receptor activation limits the extent to which it could possibly suppress respiration, even at supratherapeutic doses. This pharmacological ceiling causes it to be considerably safer in https://dihydrocodeine-3036801.blog-kids.com/38530316/details-fiction-and-buy-zopiclone-online-uk

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